Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 159371
Gene Symbol: SLC35G1
SLC35G1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker BEFREE In all, 295 patients underwent elective lung resection for pulmonary malignancy from 2015 to 2019 PRE (n = 169) and POST (n = 126) implementation of an ERAS program containing all major ERAS Society guidelines. 31851005

2019

Entrez Id: 27351
Gene Symbol: DESI1
DESI1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker BEFREE In all, 295 patients underwent elective lung resection for pulmonary malignancy from 2015 to 2019 PRE (n = 169) and POST (n = 126) implementation of an ERAS program containing all major ERAS Society guidelines. 31851005

2019

Entrez Id: 2191
Gene Symbol: FAP
FAP
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Advanced duodenal polyposis stage in FAP requires consideration of duodenal resection to prevent cancer; pylorus-preserving approach of pancreas-sparing duodenectomy (PSD) is preferred. 31850977

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Activation of STAT3 promotes expansion of cancer stem cells in triple negative breast cancer. 31850822

2020

Entrez Id: 101154753
Gene Symbol: PANDAR
PANDAR
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.050 Biomarker BEFREE Despite the fact that recent studies have revealed that lncRNA PANDAR may be a potential prognostic biomarker for patients with cancer, there has still been controversy on the prognostic value of PANDAR. 31850222

2019

Entrez Id: 10855
Gene Symbol: HPSE
HPSE
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE The diversity of outcomes attributed to heparanase and the difficulties of unequivocally determining which of these are due to its enzymatic activity is also discussed and leads us to the conclusion that heparanase is a valid, but challenging drug target for cancer. 31850210

2019

Entrez Id: 442900
Gene Symbol: MIR326
MIR326
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 Biomarker BEFREE MiR-326: Promising Biomarker for Cancer. 31849530

2019

Entrez Id: 100886964
Gene Symbol: PTCSC3
PTCSC3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker BEFREE PTCSC3 inhibits tumor growth and cancer cell stemness in gastric cancer by interacting with lncRNA Linc-pint. 31849528

2019

Entrez Id: 64422
Gene Symbol: ATG3
ATG3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker BEFREE Eventually, Western blot, plate clone formation and Transwell invasion assays proved that autophagy block could antagonize the promotive functions of ATG3 on proliferation and invasion in cancer suggesting autophagy activation accounts for the promotive role of ATG3 on proliferation and invasion in colon cancer. 31849517

2019

Entrez Id: 114548
Gene Symbol: NLRP3
NLRP3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE NLRP3 Inflammasome Mediated Interleukin-1β Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma. 31849516

2019

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE NLRP3 Inflammasome Mediated Interleukin-1β Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma. 31849516

2019

Entrez Id: 6615
Gene Symbol: SNAI1
SNAI1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE 20(R)-Ginsenoside Rg3 Influences Cancer Stem Cell Properties and the Epithelial-Mesenchymal Transition in Colorectal Cancer via the SNAIL Signaling Axis. 31849492

2019

Entrez Id: 8549
Gene Symbol: LGR5
LGR5
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression BEFREE Upon m<sup>6</sup>A methylation-induced upregulation, CBX8 interacts with KMT2b and Pol II to promote LGR5 expression in a noncanonical manner, which contributes to increased cancer stemness and decreased chemosensitivity in CC. 31849331

2019

Entrez Id: 57332
Gene Symbol: CBX8
CBX8
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.030 AlteredExpression BEFREE Aberrant expression of CBX8 has been identified in many types of cancer, but the cause of this aberrant CBX8 expression and whether CBX8 is associated with stemness properties in CC remain unknown. 31849331

2019

Entrez Id: 6696
Gene Symbol: SPP1
SPP1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE To resolve these inconsistencies, we systematically analyzed the available data to determine whether SPP1 and SPP2 are prognostic markers in the context of human cancer. 31849319

2019

Entrez Id: 81502
Gene Symbol: HM13
HM13
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.080 Biomarker BEFREE While many studies have assessed the predictive value of secreted phosphoprotein (SPP) genes in cancer, the findings have been inconsistent. 31849319

2019

Entrez Id: 6694
Gene Symbol: SPP2
SPP2
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.010 Biomarker BEFREE To resolve these inconsistencies, we systematically analyzed the available data to determine whether SPP1 and SPP2 are prognostic markers in the context of human cancer. 31849319

2019

Entrez Id: 23530
Gene Symbol: NNT
NNT
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.020 Biomarker BEFREE The long noncoding RNA nicotinamide nucleotide transhydrogenase antisense RNA 1 (<i>NNT-AS1</i>) is a key malignancy regulator in a variety of human cancers. 31848324

2019

Entrez Id: 6898
Gene Symbol: TAT
TAT
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE It was further passivated by thiolated poly(ethylene glycol)-tumor homing peptides (NGR and TAT) to improve its cancer tissue penetrating, and accurate targeting ability. 31847931

2019

Entrez Id: 65078
Gene Symbol: RTN4R
RTN4R
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.040 Biomarker BEFREE It was further passivated by thiolated poly(ethylene glycol)-tumor homing peptides (NGR and TAT) to improve its cancer tissue penetrating, and accurate targeting ability. 31847931

2019

Entrez Id: 5077
Gene Symbol: PAX3
PAX3
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE PAX3 is the key factors in cell signal transduction pathway and may be involved in the regulation of cancer cell proliferation, differentiation, and migration. 31847528

2019

Entrez Id: 1017
Gene Symbol: CDK2
CDK2
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE Finally, we suggest that the compound (PubChem ID 101874157) would be a promising scaffold to be further exploited as a potential inhibitor of CDK2 for therapeutic management of cancer after required validation. 31847444

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 GeneticVariation BEFREE Non-Coding RNAs in IGF-1R Signaling Regulation: The Underlying Pathophysiological Link between Diabetes and Cancer. 31847392

2019

Entrez Id: 3480
Gene Symbol: IGF1R
IGF1R
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker BEFREE In this review, we briefly summarize a number of well-known miRNAs and lncRNAs that regulate the IGF-1R in DM and cancer, respectively, and further discuss the potential underlying molecular pathogenesis of this disease association. 31847392

2019

Entrez Id: 3400
Gene Symbol: ID4
ID4
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.060 AlteredExpression BEFREE Detailed analyses indicated that Id4 could promote E-cadherin expression through the binding of Slug, cause the occurrence of mesenchymal-epithelial transition (MET), and inhibit cancer metastasis. 31847356

2019